Vinyl chloride and the liver
نویسندگان
چکیده
منابع مشابه
Worker exposure to vinyl chloride and poly(vinyl chloride).
The National Institute for Occupational Safety and Health (NIOSH) in early 1974 began industrial hygiene studies of vinyl chloride exposed workers. Three VC monomer plants, three VC polymerization plants, and seven PVC fabrication plants were surveyed. V polymerization plant workers and workers in one job category in VC monomer plants were exposed to average levels above 1 ppm. The highest aver...
متن کاملScreening for liver disease in vinyl chloride workers.
Following the occurrence of hepatic fibrosis and angiosarcoma in polyvinyl chloride autoclave workers, a screening programme was set up for workers at risk in a large production plant. There was no significant difference in liver function tests between workers and a control group of men in the same factory, not exposed to vinyl chloride. Four exposed workers out of 422 were found to have enlarg...
متن کاملVinyl chloride Toxicological overview
Vinyl chloride is readily and rapidly absorbed via inhalation, ingestion and through the skin At room temperature vinyl chloride is a gas, so inhalation is the major route exposure Following absorption, it is distributed through the body, with the highest concentrations found in the liver and kidneys, followed by the lungs and spleen Vinyl chloride is mainly metabolised in the liver int...
متن کاملVinyl Chloride General information
Toxic by all routes of exposure – inhalation, ingestion, skin contact Carcinogenic in humans Inhalation of vinyl chloride causes coughing, wheezing and breathlessness, headache, ataxia, drowsiness and coma Ingestion of vinyl chloride causes nausea, vomiting, diarrhoea, abdominal pain, and haematemesis may occur. Skin contact causes irritation, pain, burns and contact dermatitis. Rapid...
متن کاملQuantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013
OBJECTIVE To evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013. METHODS SMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumul...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2009
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2009.09.012